Genome editing has generated an unprecedented interest in both scientific circles and the community of lawyers and bioethicists. Once this technology becomes safe and can be used for clinical purposes, it might shake the existing ethical and legal consensus. Genome editing is forcing us to rethink the dichotomies between natural and artificial or therapy and enhancement, and it is going to cast in a new light the distinction between the stances of protecting life and giving priority to personal autonomy in reproductive rights. Moreover, by applying genome editing in practice, the division between germ line and somatic line will become blurred, which will require significant adjustments in regulation. As preimplantation genetic tests become increasingly widespread, embryo selection at in vitro fertilization clinics raises serious ethical concerns. Genome editing is still a new technology, but its potential implications suggest that once it can be successfully applied in medicine, we will have to reexamine a number of basic ethical principles and legal arguments that govern bioethics and biomedical law. This chapter attempts to look at these potential changes and analyze their implications.